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CD244
Доступные конструкции
PDBОртолог поиск: PDBe RCSB
Список идентификационных кодов PDB

1З2К , 2ПТТ , 2ПТУ

Идентификаторы
ПсевдонимыCD244 , 2B4, NAIL, NKR2B4, Nmrk, SLAMF4, молекула CD244
Внешние идентификаторыOMIM : 605554 MGI : 109294 HomoloGene : 9493 GeneCards : CD244
Расположение гена ( человек )
Chromosome 1 (human)
Chr.Хромосома 1 (человека) [1]
Chromosome 1 (human)
Genomic location for CD244
Genomic location for CD244
Группа1к23.3Начинать160 830 160 п.н. [1]
Конец160 862 887 п.н. [1]
Расположение гена ( Мышь )
Chromosome 1 (mouse)
Chr.Хромосома 1 (мышь) [2]
Chromosome 1 (mouse)
Genomic location for CD244
Genomic location for CD244
Группа1 H3 | 1 79,52 смНачинать171 559 193 п.н. [2]
Конец171 609 746 п.н. [2]
Паттерн экспрессии РНК
PBB GE CD244 220307 at fs.png
Дополнительные данные эталонного выражения
Генная онтология
Молекулярная функция• Связывание с белками MHC класса I
• Связывание с белками GO: 0001948
• активность сигнального рецептора
Сотовый компонент• плазматическая мембрана
• мембрана
• неотъемлемый компонент мембраны
• внешняя сторона плазматической мембраны
Биологический процесс• врожденный иммунный ответ
• позитивная регуляция продукции гранзима B
• процесс иммунной системы
• миграция лейкоцитов
• адаптивный иммунный ответ
• передача сигнала
• позитивная регуляция процесса биосинтеза инозитолфосфата
• иммунный ответ
• активация естественных клеток-киллеров, участвующих в иммунном ответе
Источники: Amigo / QuickGO
Ортологи
РазновидностьЧеловекМышь
Entrez

51744

18106

Ансамбль

ENSG00000122223

ENSMUSG00000004709

UniProt

Q9BZW8

Q07763

RefSeq (мРНК)

NM_001166663
NM_001166664
NM_016382

NM_018729

RefSeq (белок)

NP_001160135
NP_001160136
NP_057466

NP_061199

Location (UCSC)Chr 1: 160.83 – 160.86 MbChr 1: 171.56 – 171.61 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

CD244 (Cluster of Differentiation 244) is a human protein encoded by the CD244 gene.[5] It is also known as Natural Killer Cell Receptor 2B4[6]

This gene encodes a cell surface receptor expressed on natural killer cells (NK cells) (and some T cells) mediating non-major histocompatibility complex (MHC) restricted killing. The interaction between NK-cell and target cells via this receptor is thought to modulate NK-cell cytolytic activity. Alternatively spliced transcript variants encoding different isoforms have been found for this gene.[7]CD244 can also be expressed on non-lymphocytes such as eosinophils, mast cells and dendritic cells.[8]

See also[edit]

  • Cluster of differentiation

References[edit]

  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000122223 - Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000004709 - Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ "Entrez Gene: CD244 CD244 molecule, natural killer cell receptor 2B4".
  6. ^ Online Mendelian Inheritance in Man (OMIM): 605554
  7. ^ "CD244 molecule, natural killer cell receptor 2B4 ( Homo sapiens (human) )".
  8. ^ Georgoudaki AM, Khodabandeh S, Puiac S, Persson CM, Larsson MK, Lind M, Hammarfjord O, Nabatti TH, Wallin RP, Yrlid U, Rhen M, Kumar V, Chambers BJ (2015). "CD244 is expressed on dendritic cells and regulates their functions". Immunol Cell Biol. 93 (6): 581–90. doi:10.1038/icb.2014.124. PMID 25643613. S2CID 34400690.

Further reading[edit]

  • Vaidya SV, Mathew PA (2006). "Of mice and men: different functions of the murine and human 2B4 (CD244) receptor on NK cells". Immunol. Lett. 105 (2): 180–4. doi:10.1016/j.imlet.2006.02.006. PMID 16621032.
  • Siu G, Strauss EC, Lai E, Hood LE (1986). "Analysis of a human V beta gene subfamily". J. Exp. Med. 164 (5): 1600–14. doi:10.1084/jem.164.5.1600. PMC 2188445. PMID 3772297.
  • Latchman Y, McKay PF, Reiser H (1998). "Identification of the 2B4 molecule as a counter-receptor for CD48". J. Immunol. 161 (11): 5809–12. PMID 9834056.
  • Brown MH, Boles K, van der Merwe PA, et al. (1999). "2B4, the Natural Killer and T Cell Immunoglobulin Superfamily Surface Protein, Is a Ligand for CD48". J. Exp. Med. 188 (11): 2083–90. doi:10.1084/jem.188.11.2083. PMC 2212392. PMID 9841922.
  • Tangye SG, Lazetic S, Woollatt E, et al. (1999). "Cutting edge: human 2B4, an activating NK cell receptor, recruits the protein tyrosine phosphatase SHP-2 and the adaptor signaling protein SAP". J. Immunol. 162 (12): 6981–5. PMID 10358138.
  • Nakajima H, Cella M, Langen H, et al. (1999). "Activating interactions in human NK cell recognition: the role of 2B4-CD48". Eur. J. Immunol. 29 (5): 1676–83. doi:10.1002/(SICI)1521-4141(199905)29:05<1676::AID-IMMU1676>3.0.CO;2-Y. PMID 10359122.
  • Boles KS, Nakajima H, Colonna M, et al. (1999). "Molecular characterization of a novel human natural killer cell receptor homologous to mouse 2B4". Tissue Antigens. 54 (1): 27–34. doi:10.1034/j.1399-0039.1999.540103.x. PMID 10458320.
  • Kubin MZ, Parshley DL, Din W, et al. (1999). "Molecular cloning and biological characterization of NK cell activation-inducing ligand, a counterstructure for CD48". Eur. J. Immunol. 29 (11): 3466–77. doi:10.1002/(SICI)1521-4141(199911)29:11<3466::AID-IMMU3466>3.0.CO;2-9. PMID 10556801.
  • Parolini S, Bottino C, Falco M, et al. (2000). "X-Linked Lymphoproliferative Disease: 2b4 Molecules Displaying Inhibitory Rather than Activating Function Are Responsible for the Inability of Natural Killer Cells to Kill Epstein-Barr Virus–Infected Cells". J. Exp. Med. 192 (3): 337–46. doi:10.1084/jem.192.3.337. PMC 2193227. PMID 10934222.
  • Kumaresan PR, Mathew PA (2000). "Structure of the human natural killer cell receptor 2B4 gene and identification of a novel alternative transcript". Immunogenetics. 51 (11): 987–92. doi:10.1007/s002510000237. PMID 11003394. S2CID 450708.
  • Watzl C, Stebbins CC, Long EO (2000). "NK cell inhibitory receptors prevent tyrosine phosphorylation of the activation receptor 2B4 (CD244)". J. Immunol. 165 (7): 3545–8. doi:10.4049/jimmunol.165.7.3545. PMID 11034353.
  • Tangye SG, Cherwinski H, Lanier LL, Phillips JH (2001). "2B4-mediated activation of human natural killer cells". Mol. Immunol. 37 (9): 493–501. doi:10.1016/S0161-5890(00)00076-6. PMID 11163399.
  • Chuang SS, Pham HT, Kumaresan PR, Mathew PA (2001). "A prominent role for activator protein-1 in the transcription of the human 2B4 (CD244) gene in NK cells". J. Immunol. 166 (10): 6188–95. doi:10.4049/jimmunol.166.10.6188. PMID 11342640.
  • Morra M, Simarro-Grande M, Martin M, et al. (2001). "Characterization of SH2D1A missense mutations identified in X-linked lymphoproliferative disease patients" (PDF). J. Biol. Chem. 276 (39): 36809–16. doi:10.1074/jbc.M101305200. PMID 11477068. S2CID 39889619.
  • Morra M, Lu J, Poy F, et al. (2001). "Structural basis for the interaction of the free SH2 domain EAT-2 with SLAM receptors in hematopoietic cells". EMBO J. 20 (21): 5840–52. doi:10.1093/emboj/20.21.5840. PMC 125701. PMID 11689425.
  • Speiser DE, Colonna M, Ayyoub M, et al. (2002). "The activatory receptor 2B4 is expressed in vivo by human CD8+ effector alpha beta T cells". J. Immunol. 167 (11): 6165–70. doi:10.4049/jimmunol.167.11.6165. PMID 11714776.
  • Chuang SS, Kumaresan PR, Mathew PA (2002). "2B4 (CD244)-mediated activation of cytotoxicity and IFN-gamma release in human NK cells involves distinct pathways". J. Immunol. 167 (11): 6210–6. doi:10.4049/jimmunol.167.11.6210. PMID 11714782.
  • Bottino C, Parolini S, Biassoni R, et al. (2002). "X-linked lymphoproliferative disease: the dark side of 2b4 function". Progress in Basic and Clinical Immunology. Adv. Exp. Med. Biol. Advances in Experimental Medicine and Biology. 495. pp. 63–7. doi:10.1007/978-1-4615-0685-0_9. ISBN 978-1-4613-5194-8. PMID 11774610.
  • Aoukaty A, Tan R (2002). "Association of the X-linked lymphoproliferative disease gene product SAP/SH2D1A with 2B4, a natural killer cell-activating molecule, is dependent on phosphoinositide 3-kinase". J. Biol. Chem. 277 (15): 13331–7. doi:10.1074/jbc.M112029200. PMID 11815622.
  • Sivori S, Falco M, Marcenaro E, et al. (2002). "Early expression of triggering receptors and regulatory role of 2B4 in human natural killer cell precursors undergoing in vitro differentiation". Proc. Natl. Acad. Sci. U.S.A. 99 (7): 4526–31. Bibcode:2002PNAS...99.4526S. doi:10.1073/pnas.072065999. PMC 123681. PMID 11917118.
  • Assarsson E, Kambayshi T, Persson C, et al. (2005). "2B4 co-stimulation: NK cells and their control of adaptive immune responses". Mol. Immunol. 42 (4): 419–23. doi:10.1016/j.molimm.2004.07.021. PMID 15607793.

External links[edit]

  • CD244+protein,+human at the US National Library of Medicine Medical Subject Headings (MeSH)
  • Human CD244 genome location and CD244 gene details page in the UCSC Genome Browser.


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