These trees are native to tropical South America, Mesoamerica, and the West Indies.[2] Most are locally known as "cafetos", literally meaning "coffee plants". But while both Micropholis and the coffeeplant genus Coffea are asterids, the present genus is part of the Ericales – a quite basal asterid lineage –, while Coffea belongs to the more advanced Gentianales.
They are valued for their wood, which is used as timber, for construction and as firewood; many species are threatened by overexploitation and habitat destruction. Also, they are often used as part of catuaba, a decoction from various tree's bark claimed to have aphrodisiac and stimulant properties.
Caimitillo verde (M. garciniifolia) is an important food source of the nearly-extinct Puerto Rican amazon bird (Amazona vittata).