1MFG, 1MFL, 1MW4, 1N8Z, 1OVC, 1QR1, 1S78, 2A91, 2JWA, 2KS1, 2L4K, 3BE1, 3H3B, 3MZW, 3N85, 3PP0, 3RCD, 4GFU, 4HRL, 4HRM, 4HRN
• protein tyrosine kinase activity
• transmembrane receptor protein tyrosine kinase activity
• receptor signaling protein tyrosine kinase activity
• transmembrane signaling receptor activity
• epidermal growth factor-activated receptor activity
• protein binding
• ATP binding
• protein C-terminus binding
• growth factor binding
• protein phosphatase binding
• identical protein binding
• ErbB-3 class receptor binding
• protein heterodimerization activity
• cytoplasm
• plasma membrane
• endosome membrane
• integral component of membrane
• basolateral plasma membrane
• apical plasma membrane
• cytoplasmic vesicle
• receptor complex
• transcription, DNA-templated
• protein phosphorylation
• signal transduction
• cell surface receptor signaling pathway
• enzyme linked receptor protein signaling pathway
• transmembrane receptor protein tyrosine kinase signaling pathway
• epidermal growth factor receptor signaling pathway
• nervous system development
• axon guidance
• peripheral nervous system development
• heart development
• neuromuscular junction development
• motor neuron axon guidance
• cell proliferation
• fibroblast growth factor receptor signaling pathway
• phosphatidylinositol 3-kinase signaling
• peptidyl-tyrosine phosphorylation
• signal transduction by phosphorylation
• positive regulation of cell growth
• mammary gland development
• positive regulation of Rho GTPase activity
• regulation of microtubule-based process
• negative regulation of immature T cell proliferation in thymus
• Fc-epsilon receptor signaling pathway
• wound healing
• myelination
• positive regulation of MAP kinase activity
• innate immune response
• positive regulation of translation
• regulation of angiogenesis
• positive regulation of cell adhesion
• positive regulation of transcription from RNA polymerase I promoter
• positive regulation of transcription from RNA polymerase III promoter
• protein autophosphorylation
• neurotrophin TRK receptor signaling pathway
• phosphatidylinositol-mediated signaling
• positive regulation of epithelial cell proliferation
HER2 (англ. human epidermal growth factor receptor 2; рецептор эпидермального фактора роста, тип 2) — мембранный белок, тирозиновая протеинкиназа семейства рецепторов эпидермального фактора роста EGFR/ErbB, кодируемый геном человека ERBB2. Амплификация или повышенная экспрессия гена этого белка играет важную роль в патогенезе и прогрессировании определённых агрессивных типов рака молочной железы, является важным биомаркером и терапевтической мишенью этого вида рака.