• RNA polymerase II core promoter sequence-specific DNA binding
• RNA polymerase II core promoter sequence-specific DNA binding transcription factor activity
• double-stranded DNA binding
• sequence-specific DNA binding transcription factor activity
• signal transducer activity
• tumor necrosis factor receptor binding
• calcium ion binding
• protein binding
• enzyme binding
• CCR5 chemokine receptor binding
• identical protein binding
• negative regulation of endothelial cell proliferation
• positive regulation of mesenchymal cell proliferation
• negative regulation of mesenchymal to epithelial transition involved in metanephros morphogenesis
• regulation of transcription from RNA polymerase II promoter
• transcription from RNA polymerase II promoter
• apoptotic process
• JAK-STAT cascade
• response to nutrient
• blood circulation
• response to mechanical stimulus
• viral process
• negative regulation of angiogenesis
• cytokine-mediated signaling pathway
• lipopolysaccharide-mediated signaling pathway
• cellular response to insulin stimulus
• tumor necrosis factor-mediated signaling pathway
• response to cytokine
• negative regulation of macrophage fusion
• cellular response to interferon-beta
• response to drug
• response to hydrogen peroxide
• regulation of apoptotic process
• negative regulation of I-kappaB kinase/NF-kappaB signaling
• response to exogenous dsRNA
• response to peptide hormone
• endothelial cell migration
• positive regulation of transcription, DNA-templated
• positive regulation of transcription from RNA polymerase II promoter
• positive regulation of smooth muscle cell proliferation
• response to cAMP
• defense response to virus
• interferon-gamma-mediated signaling pathway
• regulation of interferon-gamma-mediated signaling pathway
• type I interferon signaling pathway
• regulation of type I interferon-mediated signaling pathway
• JAK-STAT cascade involved in growth hormone signaling pathway
• renal tubule development
• metanephric mesenchymal cell proliferation involved in metanephros development
• metanephric mesenchymal cell differentiation
STAT1 является членом семейства транскрипционных факторов преобразователей сигналов и активаторов транскрипции[англ.] . STAT1 участвует в положительной регуляции генов по сигналам интерферона либо типа I, типа II, или типа III. В ответ на IFN-γ стимуляцию, STAT1 образует гомодимеры или гетеродимеры с STAT3, которые связываются с GAS (Interferon G amma- A ctivated S equence) промоторным элементом; В ответ на любую IFN-α или IFN-β стимуляцию, STAT1 образует гетеродимер с STAT2, который может связываться с ISRE ( I nterferon- S timulated R esponse E lement) промоторным элементом.[1] В любом случае, связывание элемента с промотором приводит к увеличению экспрессии ISG ( I nterferon- S timulated G enes).