TRPP (transient receptor potential polycystic ) is a family of transient receptor potential ion channels which when mutated can cause polycystic kidney disease .
Subcategories [ edit ] TRPP subunits can be divided into two subcategories depending on structural similarity.
Polycystic Kidney Disease 1 (PKD1)-Like Group [ edit ] The first group, polycystic kidney disease 1 (PKD1)-like, contains polycystin-1 (Previously known as TRPP1), PKDREJ, PKD1L1, PKD1L2, and PKD1L3. Polycystin-1 contains numerous N-terminal adhesive domains that are important for cell-cell contact.[1] This group of subunits also contain a large extracellular domain with numerous polycystin motifs. These motifs are of unknown function and are located between the S6 and S7 segments. The large intracellular C-terminal segment of TRPP1 seems to interact with TRPP2 to act as a signaling complex.[2]
Polycystic Kidney Disease 2 (PKD2)-Like Group [ edit ] This group of TRPP members (previously known as TRPP2-like) are: TRPP1 (previously known as TRPP2 or PKD2), TRPP2 (previously known as TRPP3 or PKDL2), and TRPP3 (previously known as TRPP5 or polycystin-L2).[3] Unlike the previous group, which contain 11 membrane-spanning segments, this group resemble other TRP channels, having 6 membrane-spanning segments with intracellular N- and C-termini. All of the members of this group contain a coiled coil region in their C-terminus involved in the interaction with the polycystin-1 group. TRPP1 and TRPP3 form constitutively active cation-selective ion channels that are permeable to calcium. TRPP2 has also been implicated in sour taste perception. Coupling of PKD1 and TRPP1 recruits TRPP1 to the membrane. Here, its activity is decreased and it suppresses the activation of G proteins by PKD1.[2]
Group 1: polycystic kidney disease 1 (PKD1) like proteins Group 2: polycystic kidney disease 2 (PKD2) like proteins See also [ edit ] References [ edit ] External links [ edit] TRPP+Cation+Channels at the US National Library of Medicine Medical Subject Headings (MeSH) "Transient Receptor Potential Channels". IUPHAR Database of Receptors and Ion Channels . International Union of Basic and Clinical Pharmacology. "TRIP Database". a manually curated database of protein-protein interactions for mammalian TRP channels .
Inositol trisphosphate receptor Ryanodine receptor L-type/Cav α N-type/Cav α2.2 P-type/Cav α Q-type/Cav α2.1 R-type/Cav α2.3 T-type/Cav α α2 δ-subunits β-subunits γ-subunits Cation channels of sperm Two-pore channel
Epithelial sodium channel Amiloride-sensitive cation channel Nav α 1.1 1.2 1.3 1.4 1.5 1.6 1.7 1.8 1.9 7A Nav β
BK channel SK channel IK channel KCa Kv β KCNIP minK/ISK minK/ISK-like MiRP Shaker (gene)
Calcium-activated chloride channelsAnoctamin Bestrophin Chloride Channel Accessory CFTR CLCN CLIC CLNS TRPA (1) TRPC TRPM TRPML TRPN TRPP TRPV Aquaporin Voltage-dependent anion channel General bacterial porin family ConnexinAGJA1 GJA3 GJA4 GJA5 GJA8 GJA9 GJA10 BGJB1 GJB2 GJB3 GJB4 GJB5 GJB6 GJB7 C D Innexin
Ligand-gated Light-gated Voltage-gated Stretch-activated
see also disorders
4-Hydroxynonenal 4-Oxo-2-nonenal 4,5-EET 12S-HpETE 15-Deoxy-Δ12,14-prostaglandin J2 α-Sanshool (ginger, Sichuan and melegueta peppers) Acrolein Allicin (garlic) Allyl isothiocyanate (mustard, radish, horseradish, wasabi) AM404 ASP-7663 Bradykinin Cannabichromene (cannabis) Cannabidiol (cannabis) Cannabigerol (cannabis) Cinnamaldehyde (cinnamon) CR gas (dibenzoxazepine; DBO) CS gas (2-chlorobenzal malononitrile) Cuminaldehyde (cumin) Curcumin (turmeric) Dehydroligustilide (celery) Diallyl disulfide Dicentrine (Lindera spp.) Farnesyl thiosalicylic acid Formalin Gingerols (ginger) Hepoxilin A3 Hepoxilin B3 Hydrogen peroxide Icilin Isothiocyanate JT-010 Ligustilide (celery, Angelica acutiloba ) Linalool (Sichuan pepper, thyme) Methylglyoxal Methyl salicylate (wintergreen) N-Methylmaleimide Nicotine (tobacco) Oleocanthal (olive oil) Paclitaxel (Pacific yew) Paracetamol (acetaminophen) PF-4840154 Phenacyl chloride Polygodial (Dorrigo pepper) Shogaols (ginger, Sichuan and melegueta peppers) Tear gases Tetrahydrocannabinol (cannabis) Tetrahydrocannabiorcol Thiopropanal S-oxide (onion) Umbellulone (Umbellularia californica ) WIN 55,212-2 A-967079 AM-0902 Dehydroligustilide (celery) HC-030031 Nicotine (tobacco) PF-04745637 Ruthenium red
Adhyperforin (St John's wort) Diacyl glycerol GSK1702934A Hyperforin (St John's wort) Substance P DCDPC DHEA-S Flufenamic acid GSK417651A GSK2293017A Meclofenamic acid N-(p-Amylcinnamoyl)anthranilic acid Niflumic acid Pregnenolone sulfate Progesterone Pyr3 Tolfenamic acid
ADP-ribose BCTC Calcium (intracellular) CIM-0216 Cold Coolact P Cooling Agent 10 Eucalyptol (eucalyptus) Frescolat MGA Frescolat ML Geraniol Hydroxycitronellal Icilin Linalool Menthol (mint) PMD 38 Pregnenolone sulfate Rutamarin (Ruta graveolens ) Steviol glycosides (e.g., stevioside) (Stevia rebaudiana ) Sweet tastants (e.g., glucose, fructose, sucrose; indirectly) Thio-BCTC WS-12 AMG-333 Capsazepine Clotrimazole DCDPC Elismetrep Flufenamic acid Meclofenamic acid Mefenamic acid N-(p-Amylcinnamoyl)anthranilic acid Nicotine (tobacco) Niflumic acid Ononetin PF-05105679 RQ-00203078 Ruthenium red Rutamarin (Ruta graveolens ) Tolfenamic acid TPPO TRPM4-IN-5
EVP21 MK6-83 ML-SA1 ML2-SA1 PI(3,5)P2 SF-22 SN-2
Triptolide (Tripterygium wilfordii )
2-APB 5',6'-EET 9-HODE 9-oxoODE 12S-HETE 12S-HpETE 13-HODE 13-oxoODE 20-HETE α-Sanshool (ginger, Sichuan and melegueta peppers) Allicin (garlic) AM404 Anandamide Bisandrographolide (Andrographis paniculata ) Camphor (camphor laurel, rosemary, camphorweed, African blue basil, camphor basil) Cannabidiol (cannabis) Cannabidivarin (cannabis) Capsaicin (chili pepper) Carvacrol (oregano, thyme, pepperwort, wild bergamot, others) DHEA Diacyl glycerol Dihydrocapsaicin (chili pepper) Estradiol Eugenol (basil, clove) Evodiamine (Euodia ruticarpa ) Gingerols (ginger) GSK1016790A Heat Hepoxilin A3 Hepoxilin B3 Homocapsaicin (chili pepper) Homodihydrocapsaicin (chili pepper) Incensole (incense) Lysophosphatidic acid Low pH (acidic conditions) Menthol (mint) N-Arachidonoyl dopamine N-Oleoyldopamine N-Oleoylethanolamide Nonivamide (PAVA) (PAVA spray) Nordihydrocapsaicin (chili pepper) Paclitaxel (Pacific yew) Paracetamol (acetaminophen) Phenylacetylrinvanil Phorbol esters (e.g., 4α-PDD) Piperine (black pepper, long pepper) Polygodial (Dorrigo pepper) Probenecid Protons RhTx Rutamarin (Ruta graveolens ) Resiniferatoxin (RTX) (Euphorbia resinifera/pooissonii ) Shogaols (ginger, Sichuan and melegueta peppers) Tetrahydrocannabivarin (cannabis) Thymol (thyme, oregano) Tinyatoxin (Euphorbia resinifera/pooissonii ) Tramadol Vanillin (vanilla) Zucapsaicin α-Spinasterol (Vernonia tweediana ) AMG-517 AMG-9810 Asivatrep BCTC Cannabigerol (cannabis) Cannabigerolic acid (cannabis) Cannabigerovarin (cannabis) Cannabinol (cannabis) Capsazepine DCDPC DHEA DHEA-S Flufenamic acid GRC-6211 HC-067047 Lanthanum Mavatrep Meclofenamic acid N-(p-Amylcinnamoyl)anthranilic acid NGD-8243 Niflumic acid Pregnenolone sulfate RN-1734 RN-9893 Ruthenium red SB-705498 Tivanisiran Tolfenamic acid TRPV3-74a
See also: Receptor/signaling modulators • Ion channel modulators