I-SMAD или ингибитор SMAD является подклассом SMAD , которые участвуют в модуляции бета- лигандов трансформирующего фактора роста . В этот класс входят SMAD6 и SMAD7 . Они конкурируют с SMAD4 и, следовательно, регулируют транскрипцию его генных продуктов.
Внешние ссылки [ править ]
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| - Рецепторы активина 2 типа
- AMHR2
- BMPR2
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- R-SMAD ( SMAD1
- SMAD2
- SMAD3
- SMAD5
- SMAD9 )
- I-SMAD ( SMAD6
- SMAD7 )
- SMAD4
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- Цербер
- Chordin
- Декорин
- Фоллистатин
- Гремлин
- Левша
- LTBP1
- Noggin
- ПАРН
- THBS1
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- Agonists: Activin (A, B, AB)
- Avotermin
- BMP (10)
- Cetermin
- GDF (2 (BMP9))
- TGFβ (1, 2, 3)
- Antibodies: Ascrinvacumab
- Kinase inhibitors: K-02288
- ML-347 (LDN-193719, VU0469381)
- Decoy receptors: Dalantercept
- Other inhibitors: Disitertide
| - Agonists: Activin (A, B, AB)
- AMH (MIS)
- Avotermin
- BMP (5, 6, 7, 8A, 8B)
- Eptotermin alfa
- TGFβ (1, 2, 3)
- Kinase inhibitors: DMH-1
- DMH-2
- Dorsomorphin (BML-275)
- K-02288
- ML-347 (LDN-193719, VU0469381)
| - Agonists: AMH (MIS)
- BMP (2, 4, 5, 6, 7, 8A, 8B)
- Dibotermin alfa
- Eptotermin alfa
- Kinase inhibitors: DMH-2
- Dorsomorphin (BML-275)
- K-02288
| - Agonists: Activin (A, B, AB)
- GDF (1, 3, 11 (BMP11))
- Myostatin (GDF8)
- Nodal
- Antagonists: Inhibin (A, B)
- Lefty (1, 2)
- Kinase inhibitors: A 83-01
- SB-431542
- SB-505124
| - Agonists: Avotermin
- GDF (10 (BMP3B), 11 (BMP11))
- TGFβ (1, 2, 3)
- Antibodies: Fresolimumab
- Lerdelimumab
- Metelimumab
- Kinase inhibitors: A 83-01
- D-4476
- GW-788388
- LY-364947
- LY-2109761
- Galunisertib (LY-2157299)
- R-268712
- RepSox (E-616452, SJN-2511)
- SB-431542
- SB-505124
- SB-525334
- SD-208
| - Agonists: BMP (2, 4, 5, 6, 7, 8A, 8B, 15 (GDF9B))
- Dibotermin alfa
- Eptotermin alfa
- GDF (5 (BMP14), 6 (BMP13), 7 (BMP12), 9, 15)
- Radotermin
- Kinase inhibitors: DMH-2
- Dorsomorphin (BML-275)
- K-02288
| - Agonists: GDF (1, 3, 11 (BMP11))
- Nodal
- Antagonists: Lefty (1, 2)
- Kinase inhibitors: A 83-01
- SB-431542
- SB-505124
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- Agonists: Avotermin
- GDF (10 (BMP3B))
- TGFβ (1, 2, 3)
- Antibodies: Fresolimumab
- Lerdelimumab
- Metelimumab
- Kinase inhibitors: DMH-2
- LY-364947
| - Agonists: BMP (2, 4, 6, 7, 10)
- Dibotermin alfa
- Eptotermin alfa
- GDF (2 (BMP9), 5 (BMP14), 6 (BMP13), 7 (BMP12))
- Radotermin
- Antagonists: Inhibin (A, B)
| - Agonists: Activin (A, B, AB)
- BMP (2, 4, 5, 6, 7, 8A, 8B, 15 (GDF9B))
- Dibotermin alfa
- Eptotermin alfa
- GDF (1, 3, 5 (BMP14), 6 (BMP13), 7 (BMP12), 9, 11 (BMP11), 15)
- Myostatin (GDF8)
- Nodal
- Radotermin
- Antagonists: Inhibin (A, B)
- Lefty (1, 2)
- Decoy receptors: Sotatercept
| - Agonists: Activin (A, B, AB)
- BMP (2, 4, 6, 7)
- Dibotermin alfa
- Eptotermin alfa
- GDF (1, 3, 5 (BMP14), 6 (BMP13), 7 (BMP12))
- Myostatin (GDF8)
- Nodal
- Osteogenin (BMP3, BMP3A)
- Radotermin
- Antagonists: Inhibin (A, B)
- Lefty (1, 2)
- Decoy receptors: Ramatercept
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- Ligands: Avotermin
- Inhibin (A, B)
- TGFβ (1, 2, 3)
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- Endogenous antagonists/inhibitors: BAMBI
- Cerberus (CER1)
- Chordin
- DAN (PARN)
- Decorin
- Follistatin
- Gremlin (Drm)
- LTBP1
- Noggin
- TGIF
- Thrombospondin 1 (THBS1)
- Tomoregulin 1
- Antibodies: Stamulumab (against myostatin)
- TRC105 (against endoglin)
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